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Nolatrexed dihydrochloride

CAS No. 152946-68-4

Nolatrexed dihydrochloride( AG 337 | Thymitaq )

Catalog No. M17332 CAS No. 152946-68-4

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nolatrexed dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
  • Description
    Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AG 337 | Thymitaq
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Thymidylate synthase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    152946-68-4
  • Formula Weight
    357.26
  • Molecular Formula
    C14H14Cl2N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 41.67 mg/mL. 116.64 mM;
  • SMILES
    Cc1c(c2c(cc1)[nH]c(N)nc2=O)Sc1ccncc1.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hughes AN, et al. Br J Y. 2000 May;82(9):1519-27.
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