Nolatrexed dihydrochloride

Research use only, not for human use.

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

AG 337; Thymitaq

Others

Other Targets

Thymidylate synthase

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——

152946-68-4

357.26

C14H14Cl2N4OS

98%

DMSO : 41.67 mg/mL. 116.64 mM;

Cc1c(c2c(cc1)[nH]c(N)nc2=O)Sc1ccncc1.Cl.Cl

——

(-20℃)

With Ice Pack

≥ 2 years